Here's a document www.equallogic.com/.../DownloadAsset.aspx  that covers how to configure iSCSI with EQL arrays.
It's highly unlikely that you will need 6x GbE NICs for iSCSI with your configuration.

Two for ESX iSCSI use and two more for guest iSCSI initiators is best.  I.e. if you want to take advantage of ASM/ME for SQL or Exchange, directly connecting to the array from inside the Windows VM is the only way to accomplish that.

If you are going to use VMwares Round Robin you need to change the 'iops' value from 1000 to 3.   Otherwise you will not get max benefit from multiple NICs.
Solution Title
HOWTO: Change IOPs value // Round Robin for MPIO in ESXi v5.x
Solution Details
Setting default policy for EQL devices to Round Robin. So new volumes discovered will be set to Round Robin
#esxcli storage nmp satp set --default-psp=VMW_PSP_RR --satp=VMW_SATP_EQL
**These new volumes will still need to have the IOPs value changed.
To gather a list of devices use:
#esxcli storage nmp device list
You'll need the naa.<number> that corresponds to the EQL volumes in that list. That the "device number" that is used in the nextx command.
Existing volumes can be changed to Round Robin
#esxcli storage nmp device set -d naa.6090a098703e30ced7dcc413d201303e --psp=VMW_PSP_RR
You can set how many IOs are sent down one path before switching to the next. This is akin to rr_min_io under Linux.
NOTE: This will only work if the policy has been changed to Round Robin ahead of time.
The "naa.XXXXXXXXXXXXX" is the MPIO device name.
You can get a list of devices with:
#esxcli storage nmp device list
naa.6090a098703e5059e3e2e483c401f002
Device Display Name: EQLOGIC iSCSI Disk (naa.6090a098703e5059e3e2e483c401f002)
Storage Array Type: VMW_SATP_EQL
Storage Array Type Device Config: SATP VMW_SATP_EQL does not support device configuration.
Path Selection Policy: VMW_PSP_RR
Path Selection Policy Device Config: {policy=iops,iops=3,bytes=10485760,useANO=0;lastPathIndex=3: NumIOsPending=0,numBytesPending=0}
Path Selection Policy Device Custom Config:
Working Paths: vmhba36:C0:T1:L0, vmhba36:C1:T1:L0, vmhba36:C2:T1:L0, vmhba36:C3:T1:L0
This also lets you confirm the path policy "VMW_PSP_RR" Which is VMware, Path Selection Policy, Round Robin" And not the IOPs value has already been set to '3'.
#esxcli storage nmp psp roundrobin deviceconfig set -d naa.6090a098703e30ced7dcc413d201303e -I 3 -t iops
#esxcli storage nmp psp roundrobin deviceconfig get -d naa.6090a098703e30ced7dcc413d201303e
Byte Limit: 10485760
Device: naa.6090a098703e30ced7dcc413d201303e
IOOperation Limit: 3
Limit Type: Iops
Use Active Unoptimized Paths: false
Lastly you need to disable 'DelayedAck' and 'LRO'
Configuring Delayed Ack in ESX 4.0 or 4.1


To implement this workaround in ESX 4.0 or 4.1, use the vSphere Client to disable delayed ACK.
Disabling Delayed Ack in ESX 4.x or 5.0
1. Log in to the vSphere Client and select the host.
2. Navigate to the Configuration tab.
3. Select Storage Adapters.
4. Select the iSCSI vmhba to be modified.
5. Click Properties.
6. Modify the delayed Ack setting using the option that best matches your site's needs, as follows:
Modify the delayed Ack setting on a discovery address (recommended).
A. On a discovery address, select the Dynamic Discovery tab.
B. Select the Server Address tab.
C. Click Settings.
D. Click Advanced.
Modify the delayed Ack setting on a specific target.
A. Select the Static Discovery tab.
B. Select the target.
C. Click Settings.
D. Click Advanced.
Modify the delayed Ack setting globally.
A. Select the General tab.
B. Click Advanced.
(Note: if setting globally you can also use vmkiscsi-tool
# vmkiscsi-tool vmhba41 -W -a delayed_ack=0)
7. In the Advanced Settings dialog box, scroll down to the delayed Ack setting.
8. Uncheck Inherit From parent. (Does not apply for Global modification of delayed Ack)
9. Uncheck DelayedAck.
10. Reboot the ESX host.


Solution Title
HOWTO: Disable LRO in ESX v4/v5
Solution Details
Within VMware, the following command will query the current LRO value.
# esxcfg-advcfg -g /Net/TcpipDefLROEnabled
To set the LRO value to zero (disabled):
# esxcfg-advcfg -s 0 /Net/TcpipDefLROEnabled
a server reboot is required.
Also make sure you Dell switches, (6224's?) have current firmware and flowcontrol is enabled, ports, spanning tree portfast is set, and you are NOT using the default VLAN.   Put all the ports on another VLAN like 11 for example.   Jumbo frames don't work well on default VLAN.
That should give you a great start.
Regards,